ABSTRACT: Objective: To optimize the microwave vacuum drying process of Jiangzhiling tablets. METHODS: The microwave drying technology of Jiangzhiling tablets was optimized by Box-Behnken design-response interview with the relative density of extract, microwave drying equipment and drying time as independent variables and the total evaluation “normalization” of emodin, ursolic acid and oleanolic acid as dependent variables.
The contents of emodin, ursolic acid and oleanolic acid were determined by HPLC. The mobile phase was methanol-0.1% phosphoric acid (80:20), acetonitrile-methanol-0.5% ammonium acetate (67:12:21), and the detection wavelength was 254 and 210 nm, respectively.
Result: The optimum microwave vacuum drying process was to concentrate the extract to relative density of 1.27 g. mL-1, microwave power of 511 W, drying time of 27 min, and the extractions of emodin, ursolic acid and oleanolic acid were 0.321, 0.548 and 0.118 mg. g-1, respectively, which were very close to the predicted values of 0.324, 0.545 and 0.121 mg. g-1.
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